MetroDoctors September/October 2013
Links to Sections:
- Autism: From How it Works to How We Can Help More Effectively (pgs 15 - 18)
- A Wide Variety of Autism Services Available at Fraser (pgs 21 - 22)
- The Lovaas Model of Early Intensive Behavioral Intervention (pgs 19 - 20)
- Autism Training in the University of Minnesota Pediatric Residency Program (pgs 23 -24)
- Autism and the Environment: Challenges and Opportunities for Minnesota's Public Health System (pgs 25 - 27)
Autism: From How it Works to How We Can Help More Effectively (pgs 15 - 18)
Martha R. Herbert, Ph.D., M.D.
- Werner E, Dawson G. Validation of the phenomenon of autistic regression using home videotapes. Arch Gen Psychiatry 2005;62:889-95.
- Ozonoff S, Iosif AM, Young GS, et al. Onset patterns in autism: correspondence between home video and parent report. J Am Acad Child Adolesc Psychiatry 2011;50:796-806 e1.
- Herbert MR. Autism: A Brain disorder or a disorder that affects the brain? Clinical Neuropsychiatry 2005;2:354-79 (available on www.marthaherbert.org)
- Oliveira G, Diogo L, Grazina M, et al. Mitochondrial dysfunction in autism spectrum disorders: a population-based study. Dev Med Child Neurol 2005;47:185-9.
- Gargus JJ. Mitochondrial component of calcium signaling abnormality in autism. In: Chauhan A, Chauhan V, Brown T, eds. Autism: Oxidative Stress, Inflammation, and Immune Abnormalities. Boca Raton, FL: CRC Press; 2009:207-24.
- Rossignol DA, Frye RE. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Mol Psychiatry 2011:1-25.
- Wass S. Distortions and disconnections: disrupted brain connectivity in autism. Brain Cogn 2011;75:18-28.
- Muller RA. From loci to networks and back again: anomalies in the study of autism. Ann N Y Acad Sci 2008;1145:300-15.
- Muller RA, Shih P, Keehn B, Deyoe JR, Leyden KM, Shukla DK. Underconnected, but how? A survey of functional connectivity MRI studies in autism spectrum disorders. Cereb Cortex 2011;21:2233-43.
- Kong SW, Collins CD, Shimizu-Motohashi Y, et al. Characteristics and predictive value of blood transcriptome signature in males with autism spectrum disorders. PLoS One 2012;7:e49475.
- Lintas C, Sacco R, Persico AM. Genome-wide expression studies in autism spectrum disorder, Rett syndrome, and Down syndrome. Neurobiol Dis 2012;45:57-68.
- Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 2009;65:732-41.
- Mullington JM, Simpson NS, Meier-Ewert HK, Haack M. Sleep loss and inflammation. Best Pract Res Clin Endocrinol Metab 2010;24:775-84.
- Herbert MR. Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Curr Opin Neurol 2010;23:103-10.
- Schmidt RJ, Hansen RL, Hartiala J, et al. Prenatal Vitamins, One-carbon Metabolism Gene Variants, and Risk for Autism. Epidemiology 2011;22:476-85.
- Schaevitz LR, Berger-Sweeney JE. Gene-environment interactions and epigenetic pathways in autism: the importance of one-carbon metabolism. ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2012;53:322-40.
- James SJ, Melnyk S, Jernigan S, et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet 2006;141B:947-56.
- Pessah IN, Lein PJ. Evidence for Environmental Susceptibility in Autism: What We Need to Know About Gene x Environment Interactions: Humana; 2008.
- Roberts AL, Lyall K, Hart JE, et al. Perinatal Air Pollutant Exposures and Autism Spectrum Disorder in the Children of Nurses' Health Study II Participants. Environ Health Perspect 2013.
- Block ML, Calderon-Garciduenas L. Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci 2009;32:506-16.
- Roberts EM, English PB, Grether JK, Windham GC, Somberg L, Wolff C. Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the California Central Valley. Environ Health Perspect 2007 Oct;115(10):1482-9 2007.
- Buie T, Campbell DB, Fuchs GJ, 3rd, et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics 2010;125 Suppl 1:S1-18.
- Buie T, Fuchs GJ, 3rd, Furuta GT, et al. Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics 2010;125 Suppl 1:S19-29.
- Adams JB, Audhya T, McDonough-Means S, et al. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutr Metab (Lond) 2011;8:34.
- Yasuda H, Yoshida K, Yasuda Y, Tsutsui T. Infantile zinc deficiency: association with autism spectrum disorders. Sci Rep 2011;1:129.
- Kang DW, Park JG, Ilhan ZE, et al. Reduced Incidence of and Other Fermenters in Intestinal Microflora of Autistic Children. PLoS One 2013;8:e68322.
- Gonzalez A, Stombaugh J, Lozupone C, Turnbaugh PJ, Gordon JI, Knight R. The mind-body-microbial continuum. Dialogues Clin Neurosci 2011;13:55-62.
- Mulle JG, Sharp WG, Cubells JF. The gut microbiome: a new frontier in autism research. Curr Psychiatry Rep 2013;15:337.
- Williams BL, Hornig M, Parekh T, Lipkin WI. Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. mBio 2012;3.
- Guy J, Gan J, Selfridge J, Cobb S, Bird A. Reversal of neurological defects in a mouse model of Rett syndrome. Science 2007;315:1143-7.
- Hayashi ML, Rao BS, Seo JS, et al. Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice. Proc Natl Acad Sci U S A 2007;104:11489-94.
- Ehninger D, Han S, Shilyansky C, et al. Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med 2008;14:843-8.
- Derecki NC, Cronk JC, Lu Z, et al. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature 2012;484:105-9.
- Fein D, Barton M, Eigsti IM, et al. Optimal outcome in individuals with a history of autism. J Child Psychol Psychiatry 2013;54:195-205.
- Curran LK, Newschaffer CJ, Lee LC, Crawford SO, Johnston MV, Zimmerman AW. Behaviors associated with fever in children with autism spectrum disorders. Pediatrics 2007;120:e1386-92.
- Mehler MF, Purpura DP. Autism, fever, epigenetics and the locus coeruleus. Brain Res Rev 2009;59:388-92.
- Sandler RH, Finegold SM, Bolte ER, et al. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol 2000;15:429-35.
- Herbert M. Autism: From Static Genetic Brain Defect to Dynamic Gene?Environment Modulated Pathophysiology. In: Krimsky S, Gruber J, eds. Genetic Explanations: Sense and Nonsense. Cambridge, MA: Harvard University Press; 2013:122-46.
- Herbert MR. Autism: The centrality of active pathophysiology and the shift from static to chronic dynamic encephalopathy: Taylor & Francis / CRC Press; 2009: 343-387.
- Herbert MR, with Weintraub K. The Autism Revolution: Whole Body Strategies for Making Life All It Can Be. New York, NY: Random House with Harvard Health Publications; 2012.
- Fradkin JE, Roberts BT, Rodgers GP. What's preventing us from preventing type 2 diabetes? N Engl J Med 2012;367:1177-9.
A Wide Variety of Autism Services Available at Fraser (pgs 21 -22)
Pat Pulice, Executive Director
Fraser Autism Services
- Fraser Asperger's Day Treatment — focuses on social emotional development of children and teens, addressing self-esteem, anxiety, mood issues and self-regulation.
- Fraser Autism Behavioral Aide Services — one-on-one therapy to help children, teens and young adults replace inappropriate behaviors with developmentally appropriate ones.
- Fraser Autism Case Management — designed to help individuals navigate the complex social service system. Available for residents of Hennepin and Carver County.
- Fraser Autism Consultation and Training — consultation and training with schools, agencies and direct care staff to help develop intervention programs and strategies.
- Fraser Autism Day Treatment — award-winning autism program that helps children develop skills to regulate their emotions and better control their behavior.
- Fraser Autism Home Services – an intensive in-home program that helps parents find successful strategies to support their child's development.
- Fraser Autism Skills Training — services designed to improve specific skills important to a child's daily-living activities and participation in the community. Autism Skills Training can be offered individually, with families, or in groups.
- Fraser Autism Therapy Services — individual, group and family therapy sessions with licensed psychologists and mental health practitioners. Behavioral Interventions — Following the principles of Applied Behavioral Analysis,
- Fraser Behavioral Interventions - are incorporated into a treatment plan individualized to needs of the individual.
- Fraser Employment Readiness – Specialized services for work or college-bound adults with executive functioning challenges, including those on the autism spectrum.
- Fraser Feeding Therapy — evaluation and treatment to help children manage or overcome common feeding difficulties.
- Fraser Group Social Skills Training — group skills training for children and teens to build social skills and coping strategies.
- Fraser Home and Community Supports — services include in-home family support, respite care, personal support and personal care assistant (PCA) for children, adolescents and adults.
- Fraser Learn Talk Play — an innovative small group rehabilitation program for children with social communication and emotional regulation needs.
- Fraser Music Therapy — play and structured activities using music that help children improve academic, social, emotional, communication and physical skills.
- Fraser Occupational Therapy — evaluations and treatment that improve children's fine and gross motor skills, self-care, and sensory integration.
- Fraser Parent Child Interaction Therapy — available for those with autism and emotional/behavioral issues, this therapy program is designed to improve relationships and teach parents skills to manage behavior issues.
- Fraser Partnership Program — provide support services that are not traditionally covered by county or state program funding and are often provided by unpaid family caregivers.
- Fraser Person-Centered Planning — capturing what is important to a person receiving services in order to maintain or improve his/her quality of life.
- Fraser Physical Therapy — play and functional activities that improve children's mobility, motor development, posture, strength, range of motion, balance, and coordination.
- Fraser Speech-Language Therapy — play and structured activities that improve children's language and communication skills, articulation, social communication, eating and swallowing.
- Fraser TEACCH Consultation — a structured teaching model of intervention developed at the University of North Carolina.
- Fraser Transition Services – helping teens and young adults to understand and address education, employment, community living, and community integration issues as they transition into adulthood.
- Fraser Therapeutic Listening — combines a sound-based intervention with sensory integrative activities to create a comprehensive program that is effective for children with sensory challenges.
- Fraser Visual Consultation — assists families of children with autism spectrum disorders in designing visual supports and environments
Fraser General inquiries: 612-861-1688
Fraser Physician/Professional Line: 612-767-7222 Option 3
The Lovaas Model of Early Intensive Behavioral Intervention (pgs 19 - 20)
Eric Larsson, Ph. D., L.P., B.C.B.A.-D.
- Lovaas, O.I., Koegel, R., Simmons, J.Q., & Long, J.S. (1973). Some generalization and follow-up measures on autistic children in behavior therapy. Journal of Applied Behavior Analysis. 6, 131-166.
- Luce, S. C., Christian, W. P., Anderson, S. R., Troy, P. J., & Larsson, E. V., (1991). Development of a continuum of services for children and adults with autism and other severe behavior disorders. Research in Developmental Disabilities, 13, 9-25.
- Lovaas, O.I. (1987). Behavioral treatment and normal educational and intellectual functioning in young autistic children. Journal of Consulting and Clinical Psychology. 55, 3-9.
- McEachin, J.J., Smith, T., & Lovaas, O.I. (1993). Long-term outcome for children with autism who received early intensive behavioral treatment. American Journal on Mental Retardation. 97, 359-372.
- Sallows, G.O., & Graupner, T.D. (2005). Intensive Behavioral Treatment for Children With Autism: Four-Year Outcome and Predictors. American Journal on Mental Retardation, 110, 417-438.
- Cohen, H., Amerine-Dickens, M., & Smith, T., (2006). Early Intensive Behavioral Treatment: Replication of the UCLA Model in a Community Setting. Developmental and Behavioral Pediatrics, 27, S145-S155.
Eikeseth, S., Smith, T., Jahr, E., & Eldevik, S. (2007) Outcome for Children with Autism who began Intensive Behavioral Treatment Between Ages 4 and 7: A Comparison Controlled Study. Behavior Modification, 31, 264-278.
Larsson, E.V. & Riedesel, K.L. (2011, November). Outcomes of Sufficiently Funded Early Intensive Behavioral Intervention: Behavioral Assessment of Full and Partial Recovery. Paper presented at the 6th International Convention of the Association for Behavior Analysis International, Granada, Spain.
Autism Training in the University of Minnesota Pediatric Residency Program (pgs 23 -24)
Emily Borman-Shoap, M.D., and Tom Scott, M.D.
The following references are utilized by residents during the DPB rotation and are also useful for primary care clinicians in practice.
- CDC - Learn the Signs. Act Early. Autism Case Training: In-Class - NCBDDD. (n.d.). Retrieved from http://www.cdc.gov/ncbddd/actearly/ACT/class.html
- Johnson, C. P., & Myers, S. M. (2007). Identification and evaluation of children with autism spectrum disorders. Pediatrics, 120(5), 1183–215. doi:10.1542/peds.2007-2361
- Macferran, K., Major, N., Fussell, J., & High, P. (2011). Components of a Comprehensive Evaluation for ASDs. Autism Case Training: A Developmental Behavioral Pediatrics Curriculum. Retrieved from http://www.cdc.gov/ncbddd/actearly/autism/case-modules/pdf/diagnosis/Compontents of a Comprehensive Evaluation for ASDs.pdf
- Myers, S. M., & Johnson, C. P. (2007). Management of children with autism spectrum disorders. Pediatrics, 120(5), 1162–82. doi:10.1542/peds.2007-2362
- The Zuckerman Parker Handbook of Developmental and Behavioral Pediatrics for Primary Care. (2010). (p. 521). Lippincott Williams & Wilkins.
Autism and the Environment: Challenges and Opportunities for Minnesota's Public Health System (pgs 25-27)
Anne Kelly, M.D., MPH, FAAP, and Kathleen Schuler, MPH
- Ganz ML. The Lifetime Distribution of the Incremental Societal Costs of Autism. Arch Pediatr Adolesc Med. 2007;161:343-49.
- Wang L,Leslie DL. Healthcare expenditures for children withautismspectrum disorders in Medicaid.J Am Acad Child Adolesc Psychiatry. 2010;49(11):1165-71.
- Landrigan P, Lambertini L, Birnbaum L, 2012 A Research Strategy to Discover the Environmental Causes of Autism and Neurodevelopmental Disabilities. Environ Health Perspect doi:10.1289/ehp.1104285.
- DeSoto MC . Ockham's Razor and autism: the case for developmental neurotoxins contributing to a disease of neurodevelopment. Neurotoxicology. 2009;30(3):331-7.
- Wolstenholme JT, Edwards M, Shetty SR, Gatewood JD et al. Gestational exposure to bisphenol A produces transgenerational changes in behaviors and gene expression. Endocrinology 2012; 153(8): 3828-38.
- Roberts AL, Lyall K, Hart JE, Laden F et al. Perinatal air pollutant exposures and autism spectrum disorder in the children of nurses’ health study II participants. Environ Health Perspec. On line June 18, 2013.
- Fewell MS: EARNEST Consortium. Session 6: infant nutrition: future research developments in Europe. Proc Nutr Soc. 2007:66:435-41.
- Adams JB, et.al. Nutritional and metabolic status of children with autism vs neurotypical children, and the association with autism severity. Nutr Metab (Lond). 2011;8(1):34.
- Adams JB, et al. Toxicological status of children with autism vs. neurotypical children and the association with autism severity. Biol Trace Elem Res. 2013;151(2):171-80.
- Golnik A,ScalP, Wey A, Gaillard P. Autism-specific primary care medical home intervention. J Autism Dev Disord. 2012 Jun;42(6):1087-93.
- Looman WS, Presler E, Erickson MM, Garwick AW, Cady RG, Kelly AM, Finkelstein SM. Care Coordination for Children With Complex Special Health Care Needs: The Value of the Advanced Practice Nurse’s Enhanced Scope of Knowledge and Practice. J Pediatr Health Care. 2013 Jul-Aug;27(4):293-303
- Winneke G. Developmental aspects of environmental neurotoxicology: lessons from lead and polychlorinated biphenyls. J Neurol Sci. 2011 Sep 15;308(1-2):9-15Brown K, DeCoffe D, Molcan E, Gibson
- DL. Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease. Nutrients. 2012 Aug;4(8):1095-119.
- Virmani A, Pinto L, Binienda Z, Ali S. Food, Nutrigenomics, and Neurodegeneration-Neuroprotection by What You Eat! Mol Neurobiol. 2013 Jun 28. [Epub ahead of print]